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Article

Clinical Genetic Testing for APOL1: Are we There Yet?

Seminars in nephrology - 1 Nov 2017

Young Bessie A, Fullerton Stephanie Malia, Wilson James G, Cavanaugh Kerri, Blacksher Erika, Spigner Clarence, Himmelfarb Jonathan, Burke Wylie

Abstract excerpt

End-stage renal disease (ESRD) disproportionately affects African Americans, who are two to four times more likely than European Americans to develop ESRD. Two independent variants of the apolipoprotein L1 (APOL1) gene, G1 and G2, have been associated with a 7- to 10-fold greater risk of developing nondiabetic ESRD in African Americans. Those who inherit two risk variants (G1/G1, G2/G2, or G1/G2) are also more...

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Source

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Identifiers

PMID: 29110763
DOI: 10.1016/j.semnephrol.2017.07.009
PMCID: PMC6774255

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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