Article
A HRM assay for identification of low level BRAF V600E and V600K mutations using the CADMA principle in FFPE specimens.
Pathology - 1 Dec 2017
Huebner Claudia, Weber Remeny, Lloydd Richard
Abstract excerpt
Melanoma patients with BRAF V600E and V600K mutations show complete or partial response to vemurafenib. Detection assays often scan for the common V600E mutation rather than the rare V600K variant, although this mutation can be found in a high proportion of melanoma patients in the South Pacific. Herein, we describe a BRAF high resolution melting (HRM) assay that can differentiate low level of V600E and V600K...
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