Article
Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses.
Nature communications - 2 Nov 2017
Tusco Radu, Jacomin Anne-Claire, Jain Ashish, Penman Bridget S, Larsen Kenneth Bowitz, Johansen Terje, Nezis Ioannis P
Abstract excerpt
Selective autophagy is a catabolic process with which cellular material is specifically targeted for degradation by lysosomes. The function of selective autophagic degradation of self-components in the regulation of innate immunity is still unclear. Here we show that Drosophila Kenny, the homolog of mammalian IKKγ, is a selective autophagy receptor that mediates the degradation of the IκB kinase complex....
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