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Mechanisms of myeloperoxidase catalyzed oxidation of H2S by H2O2 or O2 to produce potent protein Cys-polysulfide-inducing species.

Free radical biology & medicine - 1 Dec 2017

Garai Dorottya, Ríos-González Bessie B, Furtmüller Paul G, Fukuto Jon M, Xian Ming, López-Garriga Juan, Obinger Christian, Nagy Péter

Abstract excerpt

The interaction of heme proteins with hydrogen sulfide is gaining attention as an important element in sulfide-mediated protection against oxidative stress and in regulation of redox signaling. In our previous study we reported the efficient reversible inhibition of myeloperoxidase (MPO) activity by sulfide and the kinetics of the reactions of sulfide with ferric MPO, Compound I and Compound II. Here we provide...

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PMID: 29097214
DOI: 10.1016/j.freeradbiomed.2017.10.384

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MPO

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