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Article

MAEL promoter hypermethylation is associated with de-repression of LINE-1 in human hypospermatogenesis.

Human reproduction (Oxford, England) - 1 Dec 2017

Cheng Yu-Sheng, Wee Shi-Kae, Lin Tsung-Yen, Lin Yung-Ming

Abstract excerpt

STUDY QUESTION: Does the hypermethylation of the maelstrom spermatogenic transposon silencer (MAEL) promoter and subsequent de-repression of transposable elements represent one of the causes of spermatogenic failure in infertile men? SUMMARY ANSWER: Experimental hypermethylation of a specific region (-131 to +177) of the MAEL promoter leads to decreased expression of MAEL with increased expression of the...

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Identifiers

PMID: 29095993
DOI: 10.1093/humrep/dex329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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