Alterations of testis-specific promoter methylation in cell-free seminal deoxyribonucleic acid of idiopathic nonobstructive azoospermic men with different testicular phenotypes.

Abstract excerpt

OBJECTIVE: To explore the feasibility of quantification of testicular DNA methylation from cell-free seminal DNA (cfsDNA), and analyze promoter methylation alterations in men with idiopathic nonobstructive azoospermia (NOA). DESIGN: Comparison between testicular DNA and paired cfsDNA, and among NOA patients with different testicular phenotypes. SETTING: Academic research institute and andrology practice....

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