Article
Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.
Neuroreport - 26 Oct 2011
Hunter Michael P, Nelson Marianela, Kurzer Michael, Wang Xuerong, Kryscio Richard J, Head Elizabeth, Pinna Graziano, O'Bryan John P
Abstract excerpt
Intersectin 1 (ITSN1) is a human chromosome 21 (HSA21) gene product encoding a multidomain scaffold protein that functions in endocytosis, signal transduction, and is implicated in Down's syndrome, Alzheimer's Disease, and potentially other neurodegenerative diseases through activation of c-Jun N-terminal kinase. We report for the first time that ITSN1 proteins are elevated in individuals with Down's syndrome of...
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