Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles: Next-Generation Sequencing Analysis of 6 Cases Negative for Aberrations Related to the VHL gene.

doi:10.1097/PAI.0000000000000410

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Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles: Next-Generation Sequencing Analysis of 6 Cases Negative for Aberrations Related to the VHL gene.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Mar 2018

Petersson Fredrik, Martinek Petr, Vanecek Tomas, Pivovarcikova Kristyna, Peckova Kvetoslava, Ondic Ondrej, Perez-Montiel Delia, Skenderi Faruk, Ulamec Monika, Nenutil Rudolf, Hora Milan, Svoboda Tomas, Rotterova Pavla, Dusek Martin, Michal Michal, Hes Ondrej

Abstract excerpt

We have studied a cohort of renal cell carcinomas (RCCs) with smooth-muscle stroma (N=6), which lacked any of following genetic aberrations: mutations in the VHL-gene-coding sequence, loss of heterozygosity of chromosome 3p, or hypermethylation of VHL. Using targeted next-generation sequencing, no intronic VHL mutations or mutations in selected genes involved in angiogenesis and genes frequently mutated in clear...

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PMID: 29084058
DOI: 10.1097/PAI.0000000000000410

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