Article
TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2015
Hakimi A Ari, Tickoo Satish K, Jacobsen Anders, Sarungbam Judy, Sfakianos John P, Sato Yusuke, Morikawa Teppei, Kume Haruki, Fukayama Masashi, Homma Yukio, Chen Ying-Bei, Sankin Alexander, Mano Roy, Coleman Jonathan A, Russo Paul, Ogawa Seishi, Sander Chris, Hsieh James J, Reuter Victor E
Abstract excerpt
Integrated sequencing analysis identified a group of tumors among clear cell renal cell carcinomas characterized by hotspot mutations in TCEB1 (a gene that contributes to the VHL complex to ubiquitinate hypoxia-inducible factor). We analyzed 11 tumors from two distinct cohorts with TCEB1 mutations along with an expanded cohort to assess whether these should be considered an entity distinct from clear cell renal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.