Molecular characteristics by race and ethnicity of patients with high tumor mutational burden, high microsatellite instability, and mismatch repair deficiency: Real-world data from the multi-institutional Endometrial cancer Molecularly Targeted Therapy Consortium (ECMT2).

doi:10.1016/j.ygyno.2025.07.006

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Molecular characteristics by race and ethnicity of patients with high tumor mutational burden, high microsatellite instability, and mismatch repair deficiency: Real-world data from the multi-institutional Endometrial cancer Molecularly Targeted Therapy Consortium (ECMT2).

Gynecologic oncology - 1 Aug 2025

Lee Sarah S, Secord Angeles Alvarez, Friedman Steven, Hade Erinn M, Smitherman Carson, Bisht Nikita, Borden Lindsay, Jackson Amanda L, Backes Floor, Thaker Premal, Arend Rebecca, Wright Jason D, Corr Bradley, Ko Emily, Konecny Gottfried, Podwika Sarah, Bae-Jump Victoria, Hacker Kari E, Pothuri Bhavana

Abstract excerpt

OBJECTIVE: Mismatch repair deficiency (dMMR), high microsatellite instability (MSI-H), and high tumor mutation burden (TMB-H) are predictive and prognostic biomarkers in endometrial cancer. We aimed to characterize the racial/ethnic distribution of molecular markers and the clinical characteristics among endometrial cancer patients with TMB-H and MSI-H/dMMR. METHODS: The Endometrial Cancer Molecularly Targeted...

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Identifiers

PMID: 40651147
DOI: 10.1016/j.ygyno.2025.07.006
PMCID: PMC12415845

Genes

MLH1
MSH2
MSH6
PMS2
POLE

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