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Article

Pharmacological inhibition of the transcription factor PU.1 in leukemia

29 Oct 2017

Abstract excerpt

The transcription factor PU.1 is often impaired in patients with acute myeloid leukemia (AML). Here, we used AML cells that already had low PU.1 levels and further inhibited PU.1 using either RNA interference or, to our knowledge, first-in-class small-molecule inhibitors of PU.1 that we developed specifically to allosterically interfere with PU.1-chromatin binding through interaction with the DNA minor groove...

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PMID: 29083320
DOI: 10.1172/jci92504

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