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Article

Robust Multiplexed Clustering and Denoising of Digital PCR Assays by Data Gridding.

Analytical chemistry - 21 Nov 2017

Lau Billy T, Wood-Bouwens Christina, Ji Hanlee P

Abstract excerpt

Digital PCR (dPCR) relies on the analysis of individual partitions to accurately quantify nucleic acid species. The most widely used analysis method requires manual clustering through individual visual inspection. Some automated analysis methods have emerged but do not robustly account for multiplexed targets, low target concentration, and assay noise. In this study, we describe an open source analysis software...

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PMID: 29083143
DOI: 10.1021/acs.analchem.7b02688
PMCID: PMC8045410

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KRAS

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