Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma.

doi:10.1158/1078-0432.CCR-17-0963

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Article

Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2018

Byron Sara A, Tran Nhan L, Halperin Rebecca F, Phillips Joanna J, Kuhn John G, de Groot John F, Colman Howard, Ligon Keith L, Wen Patrick Y, Cloughesy Timothy F, Mellinghoff Ingo K, Butowski Nicholas A, Taylor Jennie W, Clarke Jennifer L, Chang Susan M, Berger Mitchel S, Molinaro Annette M, Maggiora Gerald M, Peng Sen, Nasser Sara, Liang Winnie S, Trent Jeffrey M, Berens Michael E, Carpten John D, Craig David W, Prados Michael D

Abstract excerpt

Purpose: Glioblastoma is an aggressive and molecularly heterogeneous cancer with few effective treatment options. We hypothesized that next-generation sequencing can be used to guide treatment recommendations within a clinically acceptable time frame following surgery for patients with recurrent glioblastoma.Experimental Design: We conducted a prospective genomics-informed feasibility trial in adults with...

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Identifiers

PMID: 29074604
DOI: 10.1158/1078-0432.CCR-17-0963
PMCID: PMC7516926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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