Article
Clinical Manifestations and Overall Management Strategies for Duchenne Muscular Dystrophy.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Tsuda Takeshi
Abstract excerpt
Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder that causes progressive weakness and wasting of skeletal muscular and myocardium in boys due to mutation of dystrophin. The structural integrity of each individual skeletal and cardiac myocyte is significantly compromised upon physical stress due to the absence of dystrophin. The progressive destruction of systemic musculature and myocardium causes...
Topics
- Cardiomyopathies
- Central Nervous System
- Dystrophin
- Humans
- Muscle, Skeletal
- Muscular Dystrophy, Duchenne
- Mutation
- Myocardium
- Myocytes, Cardiac
- Quality of Life