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Article

Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis.

The FEBS journal - 1 Dec 2017

Verma Preeti, Kar Bibekananda, Varshney Ritu, Roy Partha, Sharma Ashwani K

Abstract excerpt

The 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/inosine monophosphate (IMP) cyclohydrolase (ATIC) catalyzes final two steps of purine nucleotide de novo biosynthetic pathway. This study reports the characterization of ATIC from Staphylococcus lugdunensis (SlugATIC). Apart from kinetic analysis and a detailed biophysical characterization of SlugATIC, the role of ATIC in cell proliferation...

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Identifiers

PMID: 29063699
DOI: 10.1111/febs.14303

Genes

ATIC

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