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Article

Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB.

The Biochemical journal - 7 Mar 2017

Paranagama Naduni, Bonnett Shilah A, Alvarez Jonathan, Luthra Amit, Stec Boguslaw, Gustafson Andrew, Iwata-Reuyl Dirk, Swairjo Manal A

Abstract excerpt

Guanosine 5'-triphosphate (GTP) cyclohydrolase-I (GCYH-I) catalyzes the first step in folic acid biosynthesis in bacteria and plants, biopterin biosynthesis in mammals, and the biosynthesis of 7-deazaguanosine-modified tRNA nucleosides in bacteria and archaea. The type IB GCYH (GCYH-IB) is a prokaryotic-specific enzyme found in many pathogens. GCYH-IB is structurally distinct from the canonical type IA GCYH...

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Identifiers

PMID: 28126741
DOI: 10.1042/BCJ20161025
PMCID: PMC5558430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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