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Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs

1 Sept 2012

Abstract excerpt

Tuberculosis is one of the major causes of infection across the world. The emergence of multi-, extensively- and totally drug-resistant strains of Mycobacterium tuberculosis contributes to the lack of therapeutic options available. The mechanisms associated with this resistance could involve mutations in genes coding for target proteins, decreased permeability, increased efflux and so on. Resistance mediated by...

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PMID: 23106274
DOI: 10.1586/eri.12.89

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