[Genetic variation in the apolipoprotein B gene].

Abstract excerpt

It is well known that coronary heart disease (CHD) is multifactorial, with environmental and inherited risk factors both playing a role. Apolipoprotein B (apo B) is of major importance in lipoprotein metabolism and might play a central role in atherogenesis. The apo B gene is the obvious candidate gene to study the relations between lipid concentrations and CHD. Some rare mutations in the apo B gene affect plasma...

Topics

• Apolipoproteins B
• Arteriosclerosis
• Chromosomes, Human, Pair 2
• Genes
• Humans
• Hypobetalipoproteinemias
• Lipids