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Article

Alterations in the placental methylome with maternal obesity and evidence for metabolic regulation

18 Oct 2017

Abstract excerpt

The inflammatory and metabolic derangements of obesity in pregnant women generate an adverse intrauterine environment, increase pregnancy complications and adverse fetal outcomes and program the fetus for obesity and metabolic syndrome in later life. We hypothesized that epigenetic modifications in placenta including altered DNA methylation/hydroxymethylation may mediate these effects. Term placental villous...

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Identifiers

PMID: 29045485
DOI: 10.1371/journal.pone.0186115

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