Article
Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits.
Aging cell - 1 Feb 2018
Huan Tianxiao, Chen George, Liu Chunyu, Bhattacharya Anindya, Rong Jian, Chen Brian H, Seshadri Sudha, Tanriverdi Kahraman, Freedman Jane E, Larson Martin G, Murabito Joanne M, Levy Daniel
Abstract excerpt
Recent studies provide evidence of correlations of DNA methylation and expression of protein-coding genes with human aging. The relations of microRNA expression with age and age-related clinical outcomes have not been characterized thoroughly. We explored associations of age with whole-blood microRNA expression in 5221 adults and identified 127 microRNAs that were differentially expressed by age at P < 3.3 × 10-4...
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