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Article

Individual CpG sites that are associated with age and life expectancy become hypomethylated upon aging

2 Feb 2017

Abstract excerpt

There is a growing interest in simple molecular biomarkers for biological aging. Age-associated DNA methylation (DNAm) changes at specific CG dinucleotides can be combined into epigenetic age predictors to estimate chronological age—and the deviation of chronological and predicted age (∆ age ) seems to be associated with all-cause mortality. In this study, we have further validated this association and analyzed...

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PMID: 28168006
DOI: 10.1186/s13148-017-0315-9

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