Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information.

doi:10.1186/1755-8794-3-1

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Article

Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information.

BMC medical genomics - 21 Jan 2010

Zhang Yonqing, De Supriyo, Garner John R, Smith Kirstin, Wang S Alex, Becker Kevin G

Abstract excerpt

BACKGROUND: The genetic contributions to human common disorders and mouse genetic models of disease are complex and often overlapping. In common human diseases, unlike classical Mendelian disorders, genetic factors generally have small effect sizes, are multifactorial, and are highly pleiotropic. Likewise, mouse genetic models of disease often have pleiotropic and overlapping phenotypes. Moreover, phenotypic...

Topics

Animals
Cluster Analysis
Databases, Genetic
Disease
Disease Models, Animal
Genetic Association Studies
Humans
Mice
Phenotype

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Identifiers

PMID: 20092628
DOI: 10.1186/1755-8794-3-1
PMCID: PMC2822734

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