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Article

A plasma proteomics method reveals links between ischemic stroke and MTHFR C677T genotype.

Scientific reports - 17 Oct 2017

Zhang Zhenchang, Yan Qi, Guo Jia, Wang Xueping, Yuan Wei, Wang Lei, Chen Lixia, Su Gang, Wang Manxia

Abstract excerpt

Methylene Tetrahydrofolate Reductase (MTHFR) catalyzes the conversion of methylene tetrahydrofolate to methylte trahydrofolate. The 677th nucleotide of the MTHFR gene is often regarded as a risk factor of cardiovascular disease. Previous studies demonstrated an elevated risk of ischemic stroke with the MTHFR677TT genotype. In this study, we employed a plasma proteomics method to investigate the connection between...

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Source

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Identifiers

PMID: 29042595
DOI: 10.1038/s41598-017-13542-6
PMCID: PMC5645471

Genes

MTHFR
DBP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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