Article
A Comparison of Heritability Estimates by Classical Twin Modeling and Based on Genome-Wide Genetic Relatedness for Cardiac Conduction Traits.
Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Dec 2017
Nolte Ilja M, Jansweijer Joeri A, Riese Hariette, Asselbergs Folkert W, van der Harst Pim, Spector Timothy D, Pinto Yigal M, Snieder Harold, Jamshidi Yalda
Abstract excerpt
Twin studies have found that ~50% of variance in electrocardiogram (ECG) traits can be explained by genetic factors. However, genetic variants identified through genome-wide association studies explain less than 10% of the total trait variability. Some have argued that the equal environment assumption for the classical twin model might be invalid, resulting in inflated narrow-sense heritability (h 2) estimates,...
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