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Article

Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models.

Molecular autism - 12 Mar 2022

Klibaite Ugne, Kislin Mikhail, Verpeut Jessica L, Bergeler Silke, Sun Xiaoting, Shaevitz Joshua W, Wang Samuel S-H

Abstract excerpt

BACKGROUND: Repetitive action, resistance to environmental change and fine motor disruptions are hallmarks of autism spectrum disorder (ASD) and other neurodevelopmental disorders, and vary considerably from individual to individual. In animal models, conventional behavioral phenotyping captures such fine-scale variations incompletely. Here we observed male and female C57BL/6J mice to methodically catalog...

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Identifiers

PMID: 35279205
DOI: 10.1186/s13229-022-00492-8
PMCID: PMC8917660

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