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Article

First Experimental Assessment of Protein Intrinsic Disorder Involvement in an RNA Virus Natural Adaptive Process.

Molecular biology and evolution - 1 Jan 2018

Charon Justine, Barra Amandine, Walter Jocelyne, Millot Pauline, Hébrard Eugénie, Moury Benoît, Michon Thierry

Abstract excerpt

Intrinsic disorder (ID) in proteins is defined as a lack of stable structure in physiological conditions. Intrinsically disordered regions (IDRs) are highly abundant in some RNA virus proteomes. Low topological constraints exerted on IDRs are expected to buffer the effect of numerous deleterious mutations and could be related to the remarkable adaptive potential of RNA viruses to overcome resistance of their...

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PMID: 29029259
DOI: 10.1093/molbev/msx249
PMCID: PMC5850501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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