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Transcriptome analysis identifies the role of Class I histone deacetylase in Alzheimer’s disease

1 Jul 2023

Abstract excerpt

Epigenetics modification is a process that does not change the sequence of deoxyribonucleic acid (DNA) in disease progression but can alter the genetic expression of the brain in Alzheimer's disease (AD). In this study, we deployed the weighted gene co-expression network analysis (WGCNA) to explore the role of Class I histone deacetylases (HDACs) in AD, which included HDAC1, HDAC2, HDAC3, and HDAC8. The aim of...

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PMID: 37449137
DOI: 10.1016/j.heliyon.2023.e18008

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