Article
In Vitro Study on Influences of UGT1A8 Gene Polymorphisms on Mycophenolate Mofetil Metabolism.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 1 Aug 2018
Zhou Zhijie, Lu Yinghao, Song Guohe, Wang Yupeng, Chen Jian, Xiao Chao, Zhong Lin, Sun Xing, Peng Zhihai, Wang Xiaoliang
Abstract excerpt
OBJECTIVES: Mycophenolate mofetil is a first-line drug after organ transplant, but there are differences in metabolism of mycophenolate mofetil among individuals. The UDP glucuronosyltransferase enzyme is the key metabolic enzyme for mycophenolate mofetil, and UGT1A8 gene polymorphisms may affect the elimination of mycophenolate mofetil in patients. Here, we conducted an in vitro study to explore the relation...
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