Article
Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice.
Circulation. Heart failure - 1 Oct 2017
Singh Sonia R, Zech Antonia T L, Geertz Birgit, Reischmann-Düsener Silke, Osinska Hanna, Prondzynski Maksymilian, Krämer Elisabeth, Meng Qinghang, Redwood Charles, van der Velden Jolanda, Robbins Jeffrey, Schlossarek Saskia, Carrier Lucie
Abstract excerpt
BACKGROUND: Alterations in autophagy have been reported in hypertrophic cardiomyopathy (HCM) caused by Danon disease, Vici syndrome, or LEOPARD syndrome, but not in HCM caused by mutations in genes encoding sarcomeric proteins, which account for most of HCM cases. MYBPC3, encoding cMyBP-C (cardiac myosin-binding protein C), is the most frequently mutated HCM gene. METHODS AND RESULTS: We evaluated autophagy in...
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