Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome.

Investigative ophthalmology & visual science - 2 Dec 2024

Belamkar Ameya, Luo Qianyi, Mahajan Neha, Abhyankar Surabhi, Jones Bryce A, Sodhi Rupinder Kaur, Pattabiraman Padmanabhan P, Levi Moshe, Bhatwadekar Ashay D

Abstract excerpt

Purpose: Alport syndrome (AS) is a genetic condition caused by a dysfunctional collagen (IV) α3α4α5 heterotrimer, leading to basement membrane instability and, ultimately, abnormalities in the kidney, inner ear, and eyes. This study aimed to characterize ocular pathology of AS by focusing on inflammatory and fibrotic markers. Methods: Col4a3tm1Dec knockout (KO) mice eyes were evaluated for the localization of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to Collagen Type IV

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connective Tissue Growth Factor

Share to Disease Models, Animal

Share to Mice, Knockout

Share to Nephritis, Hereditary

Share to Real-Time Polymerase Chain Reaction

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 39680378
DOI: 10.1167/iovs.65.14.29
PMCID: PMC11654772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome.PMID 39680378Read ↗

Elevated TGFβ signaling contributes to ocular anterior segment dysgenesis in Col4a1 mutant mice.Semantic proximity Read ↗

Insertional Mutation of the Collagen Genes Col4a3 and Col4a4 in a Mouse Model of Alport SyndromeSemantic proximity Read ↗

TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage.Semantic proximity Read ↗

Alport Syndrome: A Comprehensive Review on Genetics, Pathophysiology, Histology, Clinical and Therapeutic Perspectives.Semantic proximity Read ↗

Genotype-Based Molecular Mechanisms in Alport Syndrome.Semantic proximity Read ↗

Upregulated Expression of Integrin α1 in Mesangial Cells and Integrin α3 and Vimentin in Podocytes of Col4a3-Null (Alport) MiceSemantic proximity Read ↗

Alport syndrome. An inherited disorder of renal, ocular, and cochlear basement membranes.Semantic proximity Read ↗

Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome.Semantic proximity Read ↗

Organization and expression of basement membrane collagen IV genes and their roles in human disorders.Semantic proximity Read ↗

Basement membranes and human disease.Semantic proximity Read ↗

Alport syndrome: abnormalities of type IV collagen genes and proteins.Semantic proximity Read ↗

Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.