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Article

Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors.

European journal of human genetics : EJHG - 1 May 2019

Maerz Lars D, Casar Tena Teresa, Gerhards Julian, Donow Cornelia, Jeggo Penelope A, Philipp Melanie

Abstract excerpt

Meier-Gorlin syndrome (MGS) is a rare, congenital primordial microcephalic dwarfism disorder. MGS is caused by genetic variants of components of the origin recognition complex (ORC) consisting of ORC1-6 and the pre-replication complex, which together enable origin firing and hence genome replication. In addition, ORC1 has previously been shown to play a role in ciliogenesis. Here, we extend this work and...

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Identifiers

PMID: 30696958
DOI: 10.1038/s41431-019-0338-0
PMCID: PMC6461852

Genes

ORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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