Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type VI secretion system degeneration accelerates intestinal epithelial cell death in Escherichia coli O157:H7.

PLoS pathogens - 1 Mar 2026

Sun Zhibin, Dong Chao, Zhou Pengcheng, Guan Quanquan, Cui Zhongli, Xia Yankai, Yao Yu-Feng

Abstract excerpt

The type VI secretion system (T6SS) is a specific protein secretion apparatus that contributes to bacterial virulence. Enterohemorrhagic Escherichia coli O157:H7 (EHEC) harbors multiple prophages and can cause severe human diseases worldwide. Here, we compared the EHEC T6SS main gene cluster with its ancestral strain E. coli O55:H7 (aEPEC) and predicted 26 mutation loci in protein-coding regions. Sequence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Epithelial Cells
Share to Escherichia coli Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli O157

Share to Escherichia coli Proteins

Share to Mutation

Share to Prophages

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 41774772
DOI: 10.1371/journal.ppat.1014039
PMCID: PMC12981562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type VI secretion system degeneration accelerates intestinal epithelial cell death in Escherichia coli O157:H7.PMID 41774772Read ↗

Large-scale genomic analysis reveals the distribution and diversity of Type VI Secretion Systems in <i>Escherichia coli</i>Semantic proximity Read ↗

Highly Pathogenic Clone of Shiga Toxin–ProducingEscherichia coliO157:H7, England and WalesSemantic proximity Read ↗

Stx-Phages: Drivers and Mediators of the Evolution of STEC and STEC-Like PathogensSemantic proximity Read ↗

Rapidly evolving orphan immunity genes protect human gut bacteria from intoxication by the type VI secretion systemSemantic proximity Read ↗

In silico Analyses of Core Proteins and Putative Effector and Immunity Proteins for T6SS in Enterohemorrhagic E. coliSemantic proximity Read ↗

The N-terminal domain of EspF induces host cell apoptosis after infection with enterohaemorrhagic Escherichia coli O157:H7.Semantic proximity Read ↗

High genetic diversity and different type VI secretion systems in Enterobacter species revealed by comparative genomics analysis.Semantic proximity Read ↗

Mucus-Activatable Shiga Toxin Genotype stx2d in Escherichia coli O157:H7.Semantic proximity Read ↗

Molecular Biology of Escherichia coli Shiga Toxins’ Effects on Mammalian CellsSemantic proximity Read ↗

Large-scale discovery of candidate type VI secretion effectors with antibacterial activitySemantic proximity Read ↗

Characterization of Seven Shiga Toxin Phages Induced from Human-Derived Shiga Toxin-Producing Escherichia coliSemantic proximity Read ↗

Unraveling enterohemorrhagic Escherichia coli infection: the promising role of dietary compounds and probiotics in bacterial elimination and host innate immunity boostingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.