Article
Full-length mutation search of the TP53 gene in acute myeloid leukemia has increased significance as a prognostic factor.
Annals of hematology - 1 Jan 2018
Terada Kazuki, Yamaguchi Hiroki, Ueki Toshimitsu, Usuki Kensuke, Kobayashi Yutaka, Tajika Kenji, Gomi Seiji, Kurosawa Saiko, Miyadera Keiki, Tokura Taichiro, Omori Ikuko, Marumo Atushi, Fujiwara Yusuke, Yui Shunsuke, Ryotokuji Takeshi, Osaki Yoshiki, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Wakita Satoshi, Tamai Hayato, Fukuda Takahiro, Inokuchi Koiti
Abstract excerpt
TP53 gene abnormality has been reported to be an unfavorable prognostic factor in acute myeloid leukemia (AML). However, almost all studies of TP53 gene abnormality so far have been limited to mutation searches in the DNA binding domain. As there have been few reports examining both mutation and deletion over the full-length of the TP53 gene, the clinical characteristics of TP53 gene abnormality have not yet been...
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