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Article

The Incorporation of Ribonucleotides Induces Structural and Conformational Changes in DNA.

Biophysical journal - 3 Oct 2017

Meroni Alice, Mentegari Elisa, Crespan Emmanuele, Muzi-Falconi Marco, Lazzaro Federico, Podestà Alessandro

Abstract excerpt

Ribonucleotide incorporation is the most common error occurring during DNA replication. Cells have hence developed mechanisms to remove ribonucleotides from the genome and restore its integrity. Indeed, the persistence of ribonucleotides into DNA leads to severe consequences, such as genome instability and replication stress. Thus, it becomes important to understand the effects of ribonucleotides incorporation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28978432
DOI: 10.1016/j.bpj.2017.07.013
PMCID: PMC5627062

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