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Article

Ageing as a risk factor for ALS/FTD.

Human molecular genetics - 1 Oct 2017

Niccoli Teresa, Partridge Linda, Isaacs Adrian M

Abstract excerpt

Like many other neurodegenerative diseases, age is a major risk factor in the development of ALS/FTD. But why is this the case? Recent genetic advances have highlighted some of pathways involved in the development of disease, and, strikingly, they appear to substantially overlap with those known to directly modulate the ageing process. Many ALS/FTD linked genes play a direct role in autophagy/lysosomal...

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PMID: 28977441
DOI: 10.1093/hmg/ddx247

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