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Editor's Highlight: High-Throughput Functional Genomics Identifies Modulators of TCE Metabolite Genotoxicity and Candidate Susceptibility Genes.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2017

De La Rosa Vanessa Y, Asfaha Jonathan, Fasullo Michael, Loguinov Alex, Li Peng, Moore Lee E, Rothman Nathaniel, Nakamura Jun, Swenberg James A, Scelo Ghislaine, Zhang Luoping, Smith Martyn T, Vulpe Chris D

Abstract excerpt

Trichloroethylene (TCE), an industrial chemical and environmental contaminant, is a human carcinogen. Reactive metabolites are implicated in renal carcinogenesis associated with TCE exposure, yet the toxicity mechanisms of these metabolites and their contribution to cancer and other adverse effects remain unclear. We employed an integrated functional genomics approach that combined functional profiling studies in...

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PMID: 28973557
DOI: 10.1093/toxsci/kfx159
PMCID: PMC5837773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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