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Article

Rapamycin and CHIR99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53-Dependent Apoptosis.

Journal of the American Heart Association - 2 Oct 2017

Qiu Xiao-Xu, Liu Yang, Zhang Yi-Fan, Guan Ya-Na, Jia Qian-Qian, Wang Chen, Liang He, Li Yong-Qin, Yang Huang-Tian, Qin Yong-Wen, Huang Shuang, Zhao Xian-Xian, Jing Qing

Abstract excerpt

BACKGROUND: Cardiomyocytes differentiated from human pluripotent stem cells can serve as an unexhausted source for a cellular cardiac disease model. Although small molecule-mediated cardiomyocyte differentiation methods have been established, the differentiation efficiency is relatively unsatisfactory in multiple lines due to line-to-line variation. Additionally, hurdles including line-specific low expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28971953
DOI: 10.1161/JAHA.116.005295
PMCID: PMC5721819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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