Article
Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC).
Scientific reports - 2 Oct 2017
von Mentzer Astrid, Tobias Joshua, Wiklund Gudrun, Nordqvist Stefan, Aslett Martin, Dougan Gordon, Sjöling Åsa, Svennerholm Ann-Mari
Abstract excerpt
The ability to colonize the small intestine is essential for enterotoxigenic Escherichia coli (ETEC) to cause diarrhea. Although 22 antigenically different colonization factors (CFs) have been identified and characterized in ETEC at least 30% of clinical ETEC isolates lack known CFs. Ninety-four whole genome sequenced "CF negative" isolates were searched for novel CFs using a reverse genetics approach followed by...
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