Article
Functional analysis of colonization factor antigen I positive enterotoxigenic Escherichia coli identifies genes implicated in survival in water and host colonization.
Microbial genomics - 1 Jun 2021
Abd El Ghany Moataz, Barquist Lars, Clare Simon, Brandt Cordelia, Mayho Matthew, Joffre Enrique, Sjöling Åsa, Turner A Keith, Klena John D, Kingsley Robert A, Hill-Cawthorne Grant A, Dougan Gordon, Pickard Derek
Abstract excerpt
Enterotoxigenic Escherichia coli (ETEC) expressing the colonization pili CFA/I are common causes of diarrhoeal infections in humans. Here, we use a combination of transposon mutagenesis and transcriptomic analysis to identify genes and pathways that contribute to ETEC persistence in water environments and colonization of a mammalian host. ETEC persisting in water exhibit a distinct RNA expression profile from...
Topics
- Animals
- Disease Models, Animal
- Enterotoxigenic Escherichia coli
- Escherichia coli Infections
- Escherichia coli Proteins
- Female
- Fimbriae Proteins
- Fimbriae, Bacterial
- Genes, Bacterial