Article
Progressive familial intrahepatic cholestasis (PFIC) type 1, 2, and 3: a review of the liver pathology findings.
Seminars in liver disease - 1 Feb 2011
Morotti Raffaella A, Suchy Frederick J, Magid Margret S
Abstract excerpt
Progressive familial intrahepatic cholestatic diseases encompass a group of autosomal recessive hereditary diseases, which usually present in infancy or childhood, with cholestasis of hepatocellular origin. The currently preferred nomenclature for the three PFIC disorders that have been characterized to date is FIC1 deficiency, BSEP deficiency, and MDR3 deficiency, relating to mutations in the specific genes...
Topics
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 11
- ATP-Binding Cassette Transporters
- Adenosine Triphosphatases
- Cholestasis, Intrahepatic
- Disease Progression
- Genetic Predisposition to Disease
- Heredity
- Humans