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Article

Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura.

Developmental cell - 11 Sept 2017

Tischfield Max A, Robson Caroline D, Gilette Nicole M, Chim Shek Man, Sofela Folasade A, DeLisle Michelle M, Gelber Alon, Barry Brenda J, MacKinnon Sarah, Dagi Linda R, Nathans Jeremy, Engle Elizabeth C

Abstract excerpt

Dural cerebral veins (CV) are required for cerebrospinal fluid reabsorption and brain homeostasis, but mechanisms that regulate their growth and remodeling are unknown. We report molecular and cellular processes that regulate dural CV development in mammals and describe venous malformations in humans with craniosynostosis and TWIST1 mutations that are recapitulated in mouse models. Surprisingly, Twist1 is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28844842
DOI: 10.1016/j.devcel.2017.07.027
PMCID: PMC5595652

Genes

TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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