Article
High mRNA expression of splice variant SYK short correlates with hepatic disease progression in chemonaive lymph node negative colon cancer patients.
PloS one - 1 Jan 2017
Coebergh van den Braak Robert R J, Sieuwerts Anieta M, Kandimalla Raju, Lalmahomed Zarina S, Bril Sandra I, van Galen Anne, Smid Marcel, Biermann Katharina, van Krieken J Han J M, Kloosterman Wigard P, Foekens John A, Goel Ajay, Martens John W M, IJzermans Jan N M
Abstract excerpt
OBJECTIVE: Overall and splice specific expression of Spleen Tyrosine Kinase (SYK) has been posed as a marker predicting both poor and favorable outcome in various epithelial malignancies. However, its role in colorectal cancer is largely unknown. The aim of this study was to explore the prognostic role of SYK in three cohorts of colon cancer patients. METHODS: Total messenger RNA (mRNA) expression of SYK, SYK(T),...
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