Human Organ Culture: Updating the Approach to Bridge the Gap from In Vitro to In Vivo in Inflammation, Cancer, and Stem Cell Biology

Abstract excerpt

Human studies, critical for developing new diagnostics and therapeutics, are limited by ethical and logistical issues and preclinical animal studies are often poor predictors of human responses. Standard human cell cultures can address some of these concerns but the absence of the normal tissue microenvironment can alter cellular responses. Three-dimensional (3D) cultures that position cells on synthetic...

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