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Article

HP1α is highly expressed in glioma cells and facilitates cell proliferation and survival.

Cancer biomarkers : section A of Disease markers - 6 Dec 2017

Lai Xianliang, Deng Zhifeng, Guo Hua, Zhu Xingen, Tu Wei

Abstract excerpt

Epigenetic alteration plays critical roles in gliomagenesis by regulating gene expression through modifications of Histones and DNA. Trimethylation of H3K9, an essential repressed transcription mark, and one of its methyltransferase, SUV39H1, are implicated in glioma pathogenesis and progression. We find that the protein level of HP1α, a reader of H3K9me3 is elevated in GOS3 and 1321N1 glioma cell lines. H3K9me3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28946550
DOI: 10.3233/CBM-170249

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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