Array comparative genomic hybridization analysis does not show genetic alterations in spermatozoa and offspring generated after spermatogonial stem cell transplantation in the mouse.

Abstract excerpt

BACKGROUND: The most promising procedure to restore fertility in male childhood cancer patients is spermatogonial stem cell transplantation (SSCT). Although the efficiency of SSCT has been proven in the mouse model, its safety needs to be investigated too before considering any implementation in the clinic. To examine the incidence of genetic abnormalities after SSCT, the karyotypes of donor-derived spermatozoa...

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