Article
Differential methylation of lipid metabolism and X-linked inheritance genes is associated with low placental efficiency, impaired fatty acid metabolism and oxidative stress in the placenta of hypercholesterolemic mothers.
Atherosclerosis - 1 Apr 2026
Jayalekshmi V S, Basu Budhaditya, Srijith Sreelekshmi, Krishna Geethu, Rafeekha P, Vidyalekshmy R, Ramachandran Surya
Abstract excerpt
BACKGROUND: Maternal hypercholesterolemia (MHC), characterized by elevated cholesterol levels in mothers during gestation, increases the risk of atherosclerosis in offspring. This study seeks to uncover how in-utero fetal programming may be linked to changes in methylation patterns in the placenta, potentially affecting fetal gene expression. METHODS: Pregnant subjects who were within the first 100 days of...
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