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Article

Bacteria- and IMD pathway-independent immune defenses against Plasmodium falciparum in Anopheles gambiae.

PloS one - 1 Jan 2013

Blumberg Benjamin J, Trop Stefanie, Das Suchismita, Dimopoulos George

Abstract excerpt

The mosquito Anopheles gambiae uses its innate immune system to control bacterial and Plasmodium infection of its midgut tissue. The activation of potent IMD pathway-mediated anti-Plasmodium falciparum defenses is dependent on the presence of the midgut microbiota, which activate this defense system upon parasite infection through a peptidoglycan recognition protein, PGRPLC. We employed transcriptomic and reverse...

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Identifiers

PMID: 24019865
DOI: 10.1371/journal.pone.0072130
PMCID: PMC3760850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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