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A clinically meaningful fetal hemoglobin threshold for children with sickle cell anemia during hydroxyurea therapy

15 Sept 2017

Abstract excerpt

Abstract Hydroxyurea has proven clinical benefits and is recommended to be offered to all children with sickle cell anemia (SCA), but the optimal dosing regimen remains controversial. Induction of red blood cell fetal hemoglobin (HbF) by hydroxyurea appears to be dose‐dependent. However, it is unknown whether maximizing HbF% improves clinical outcomes. HUSTLE (NCT00305175) is a prospective observational study...

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PMID: 28913922
DOI: 10.1002/ajh.24906

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