Article
Hydroxyurea therapy for diverse pediatric populations with sickle cell disease.
Seminars in hematology - 1 Jul 1997
Rogers Z R
Abstract excerpt
Hydroxyurea (HU) is the first widely used treatment to have an impact on the severity of disease in adult patients with sickle cell anemia, but limited data are available for younger patients or those with variant genotypes. We reviewed 324 months of experience with HU in 16 patients from 5.3 to 18.4 years of age treated for 6 to 50 months. The major toxicity was reversible neutropenia. Linear growth continued...
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