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Article

Inflammation polymorphisms and prostate cancer risk in Jamaican men: Role of obesity/body size.

Gene - 15 Dec 2017

Dubey Bhawna, Jackson Maria D, Zeigler-Johnson Charnita, Devarajan Karthik, Flores-Obando Rafael E, McFarlane-Anderson Norma, Tulloch-Reid Marshall K, Aiken William, Kimbro Kevin, Jones Dominique Z, Kidd LaCreis R, Ragin Camille

Abstract excerpt

African ancestry and obesity are associated with higher risk of prostate cancer (PC). In a pilot study, we explored interactions between obesity (as measured by waist to hip ratio (WHR)) and inflammatory SNPs in relation to PC risk among Jamaican men. This study evaluated 87 chemokine and cytokine associated SNPs in obese and normal weight cases (N=109) and controls (N=102) using a stepwise penalized logistic...

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Identifiers

PMID: 28903065
DOI: 10.1016/j.gene.2017.09.016
PMCID: PMC5645041

Genes

CCR7
CCR5
CCR6
CCR9
RNASEL

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